XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant inhibitor of NaV1.6, with an IC50 of 41 nM for hNaV1.6. It also effectively blocks NaV1.2, showing an IC50 of 125 nM. This compound exhibits anticonvulsant activity.
- Highly potent and isoform-selective NaV1.6 inhibitor.
- Effective in blocking NaV1.2.
- Demonstrates anticonvulsant activity.
- Shows good metabolic stability in human liver microsomes and hepatocytes.
- Possesses low potential for MDR1 mediated efflux.
- CNS-penetrant.